Thursday, July 5th, 2012
| 08:45 - 09:30 | Registration & Welcome Coffee | |
| 09:30 | Welcome/ Gabriele Haeusler (Pediatric Department, Medical University of Vienna, Austria) | |
| Session I | ||
| Pathways/Regulators Chairs: Lars Sävendahl (Karolinska Institutet/ Stockholm, Sweden)/ Jan-Maarten Wit (LUMC Leiden/ The Netherlands) | ||
| 09:45 - 10:15 | L01: Synthesizing bioinformatic, expression microarray, and genome-wide association analyses to discover pathways regulating the human growth plate Jeff Baron (National Institutes of Health/ Bethesda, USA) | |
| 10:15 - 10:30 | A01: Heparan sulphate upholds osteoblastic lineage (M. Wiweger/ Leiden, The Netherlands) | |
| 10:30 - 10:45 | A02: Identification of posttranscriptional regulators of chondrocyte differentiation (H. Ehlen/ Cologne, Germany) | |
| 10:45 - 11:15 | L02: Intraspecies variation in growth rates: Growth plate morphology and role of growth plate regulators Marianna Tryfonidou (Utrecht University/ The Netherlands) | |
| 11:15 - 11:30 | Coffee&Tea break | |
| Session II | ||
| IGF-I and the Growth plate. Chairs: Ola Nilsson (Karolinksa, NIH)/ Werner Schlegel (Medical University of Vienna, Austria) | ||
| 11:30 - 12:00 | L03: GH/IGF-I signalling within the growth plate: Established concepts and current insights Colin Farquharson (University of Edinburgh/ UK) | |
| 12:00 - 12:15 | A03: Increased GH signalling independent of IGF-1 is associated with increased linear growth and bone size in the SOCS2 knockout mouse (R. Dobie/ Edinburgh, UK) | |
| 12:15 - 12:30 | A04: Lack of the chondrocyte IGF-I receptor leads to perinatal death and alterations in extracellular matrix protein expression (J. Heilig/ Cologne, Germany) | |
| 12:30 - 13:45 | Lunch break | |
| Session III | ||
| Estrogens and the Growth plate. Chair: Jeff Baron (National Institutes of Health/ Bethesda, USA) | ||
| 13:45 - 14:15 | L04: Update on the role of estrogen in growth plate senescence and epiphyseal fusion. Ola Nilsson (Karolinska, Stockholm&NIH, USA) | |
| Session IV | ||
| Nutrition and Growth. Chairs: Jeff Baron (National Institutes of Health / Bethesda, USA)/ Galia Gat-Yablonski (SCMC/ Tel Aviv, Israel) | ||
| 14:15 - 14:45 | L05: Nutrition and Growth Moshe Phillip (SCMC/ Tel Aviv, Israel) | |
| 14:45 - 15:00 | A05: HDACS ARE INVOVLED IN NUTRITIONAL CATCH-UP GROWTH (G. Pinto/ Tel Aviv, Israel) | |
| 15:00 - 15:15 | A06: The role of Omega-3 in bone elongation. (E. Monsonego-Ornan/ Rehovot, Israel) | |
| 15:15 - 16:00 | A07: Reduced bone quality during nutritional induced catch up growth. (R. Pando/ Tel Aviv, Israel) | |
| 16:00 - 16:15 | Coffee break | |
| Session V | ||
| Inflammation and the Growth plate. New Therapies Chair: Efrat Monsonego-Ornan (The Hebrew University of Jerusalem/ Rehovot, Israel) | ||
| 16:15 - 16:45 | L06: Impact of chronic inflammation on the growth plate Lars Sävendahl (Karolinska/ Stockholm, Sweden) | |
| 16:45 - 17:00 | A08: IL-1beta acts at the switch between proliferation and differentiation in chondrocytes and is a negative regulator of bone quality (S. Simsa-Maziel/ Rehovot, Israel) | |
| 17:00 - 17:15 | A09: Humanin prevents bone growth impairment in mice treated with the anti-cancer drug, bortezomib. (E. Erikson/ Stockholm, Sweden) | |
| Break | ||
| 19:00 - 19:45 | Guest Lecture: "RANKL: from bones to breast cancer" Josef Penninger (Institute for Molecular Biotechnology of the Austrian Academy of Sciences/ Vienna, Austria) Chair: Gabriele Haeusler (Pediatric Department, Medical University of Vienna, Austria) | |
| 20:00 | Arkadenhof Dinner |
Friday, July 6th, 2012
| 09:00 - 09:30 | L07: A clinician's journey through the growth plate: from stem cells to apoptosis Jan-Maarten-Wit (Leiden University, The Netherlands) Chair: Moshe Phillips (SCMC/ Tel Aviv, Israel) | |
| Session VI | ||
| Mineralization. Chairs: Colin Farquharson (University of Edinburgh/ UK) / Gabriele Haeusler (Pediatric Department, Medical University of Vienna, Austria) | ||
| 09:30 - 10:00 | L08: Genes and mechanisms behind mineralization in physiological and pathological states Dov Tiosano (The Rappaport Faculty of Medicine/ Haifa, Israel) | |
| 10:00 - 10:15 | A10: Regulation of chondrocyte matrix mineralisation by the MEPE-ASARM axis. (K. Staines/ Edinburgh, UK) | |
| 10:15 - 10:30 | A11: Fibroblast growth factor 23 and Klotho are present in the growth plate. (A. Raimann/ Medical University of Vienna, Austria) | |
| 10:30 - 11:00 | Coffee break | |
| Session VII | ||
| Mechanical mechanisms , bone development/Surgical therapies. Chair: Monika Egerbacher (University of Veterinary Medicine/ Vienna, Austria)/ Catharina Chiari (Medical University of Vienna, Austria) | ||
| 11:00 - 11:30 | L09: Mechano-signaling in chondrocytes, does the primary cilium play a role? (E. Monsunego-Ornan/ Rehovot, Israel) | |
| 11:30 - 11:45 | A12: GREM1, FRZB and DKK1 are key regulators of human articular cartilage homeostasis (J. Emons/ Leiden, The Netherlands) | |
| 11:45 - 12:00 | A13: Guided growth in children with skeletal dysplasias. (S. Farr/ Vienna) | |
| 12:00 - 12:15 | A14: The impact of fracture stability on the turn-over of the near-by growth plate. (E. Fischerauer/ Graz, Austria) | |
| 12:15 - 12:30 | A15: Radiologic, Computertomographic and histologic evaluation of the development of carpal bones in the pig. (M. Egerbacher/ Vienna, Austria) | |
| 12:30 | Closing of Meeting | |
| 12:30 | Lunch | |
| 15:00 - 17:00 | Excursion |